Reactome | SENP1 [cytosol]

SENP1 [cytosol]

Stable Identifier

R-HSA-9715128

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOF GTPase cycle (Homo sapiens)
        
        RHOF binds effectors at the plasma membrane (Homo sapiens)
        
        RHOF effectors [cytosol] (Homo sapiens)
        
        SENP1 [cytosol] (Homo sapiens)
        
        RHOF:GTP:RHOF effectors [plasma membrane] (Homo sapiens)
        
        RHOF effectors [cytosol] (Homo sapiens)
        
        SENP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0U3 SENP1

Gene Names

SENP1

Chain

chain:1-644

Reference Genes

BioGPS Gene:29843 SENP1

COSMIC (genes):SENP1 SENP1

CTD Gene:29843 SENP1

dbSNP Gene:29843 SENP1

ENSEMBL:ENSG00000079387 SENP1

HGNC:17927 SENP1

KEGG Gene (Homo sapiens):29843 SENP1

Monarch:29843 SENP1

NCBI Gene:29843 SENP1

OMIM:612157 SENP1

UCSC:Q9P0U3 SENP1

Reference Transcript

Other Identifiers

0006770593

11739940_a_at

11739941_s_at

1552812_a_at

16763853

226619_at

29843

3452969

3452971

3452972

3452973

3452974

3452975

3452977

3452979

3452980

3452991

3452992

3452993

3452994

3452995

3452996

3453000

3453002

3453003

3453004

3453008

3453010

3453011

3453014

3453015

3453016

3453017

64891_at

66230_at

7962760

A_23_P204536

A_24_P167412

A_33_P3304528

GE81939

GO:0003674

GO:0004175

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005925

GO:0006464

GO:0006508

GO:0006919

GO:0007165

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0009058

GO:0016787

GO:0016926

GO:0031965

GO:0034641

GO:0043226

GO:0045944

GO:0070140

GO:0097190

HMNXSV003032392

Hs.66450.0.S2_3p_at

Hs2.66450.1.S1_3p_s_at

ILMN_1709415

ILMN_3242851

PH_hs_0024495

TC12001443.hg

Participates

as a candidate of

RHOF effectors [cytosol] (Homo sapiens)

Other forms of this molecule

SENP1 [nucleoplasm]

Inferred To

si:dkey-21c19.3 [cytosol] (Danio rerio)

Ulp1 [cytosol] (Drosophila melanogaster)

SENP1 [cytosol] (Bos taurus)

SENP1 [cytosol] (Canis familiaris)

SENP1 [cytosol] (Gallus gallus)

SENP1 [cytosol] (Sus scrofa)

ulp-2 [cytosol] (Caenorhabditis elegans)

Senp1 [cytosol] (Mus musculus)

Senp1 [cytosol] (Rattus norvegicus)

Homologues of SENP1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001254523.1, NP_001254524.1

Guide to Pharmacology - Targets

2414

OpenTargets

ENSG00000079387

GeneCards

Q9P0U3

ZINC - Substances

SENP1_HUMAN

HPA

ENSG00000079387-SENP1

ZINC target

Q9P0U3

Ensembl

ENSP00000394791, ENST00000549518, ENSP00000447328, ENSP00000450076, ENST00000448372, ENST00000549595, ENSG00000079387

PRO

Q9P0U3

Pharos - Targets

Q9P0U3

ZINC - Predictions - Purchasable

SENP1_HUMAN

PDB

2IYD, 2CKH, 2IYC, 6NNQ, 2XPH, 2IY1, 2G4D, 2XRE, 2CKG, 2IY0

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.87	12
UniProt:P61956 SUMO2	5	SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.743	6
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.591	4

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