BIL scavenges O2.-

Stable Identifier
R-HSA-9709879
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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BIL scavenges O2.-
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Bilirubin (BIL) is a physiologic antioxidant. It has a unique redox activity towards superoxide radicals (O2•−) which it readily scavenges. Bilirubin’s redox activity is particularly important in the brain, where it prevents excitotoxicity and neuronal death by scavenging O2•− during NMDA neurotransmission (Vasavda et al, 2019).
Literature References
PubMed ID Title Journal Year
31353321 Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide

Vasavda, C, Kothari, R, Malla, AP, Tokhunts, R, Lin, A, Ji, M, Ricco, C, Xu, R, Saavedra, HG, Sbodio, JI, Snowman, AM, Albacarys, L, Hester, L, Sedlak, TW, Paul, BD, Snyder, SH

Cell Chem Biol 2019
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Authored
Stephan, R  (2020-12-14)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-12-18)
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