Impaired BRCA2 binding to RAD51

Stable Identifier
R-HSA-9709570
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Impaired BRCA2 binding to RAD51
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A critical function of BRCA2 is to bind RAD51 and nucleate RAD51 filament formation on single-stranded DNA. BRCA2 has two regions that interact with RAD51: 8 BRC repeats encoded by exon11 (Bork et al. 1996, Wong et al. 1997) and a C-terminal RAD51 binding domain called TR2 (Sharan et al. 1997).
Literature References
PubMed ID Title Journal Year
8673099 Internal repeats in the BRCA2 protein sequence

Bork, P, Blomberg, N, Nilges, M

Nat Genet 1996
9126738 Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, SK, Morimatsu, M, Albrecht, U, Lim, DS, Regel, E, Dinh, C, Sands, A, Eichele, G, Hasty, P, Bradley, A

Nature 1997
9405383 RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

Wong, AK, Pero, R, Ormonde, PA, Tavtigian, SV, Bartel, PL

J Biol Chem 1997
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
BioModels Database
Authored
Orlic-Milacic, M  (2020-12-11)
Reviewed
Liu, J  (2022-01-26)
Le, HP  (2022-01-26)
Heyer, WD  (2022-01-26)
Created
Orlic-Milacic, M  (2020-12-15)
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