A small but significant fraction of XPO1 (CRM1) binds to BACH1. Several cysteine–proline (CP) dipeptide sequence in BACH1 are involved in heme binding, they also contain a nuclear export signal. The simplest model is that this region is involved in a heme-regulated interaction with XPO1 that mediates nuclear export. While XPO1 bound to BACH1 in GST pull-down assays, the nature of this interaction has yet to be extensively characterized (Suzuki et al, 2004).
Sun, J, Hira, S, Yamazaki, C, Yoshida, M, Igarashi, K, Ikeda-Saito, M, Suzuki, H, Zenke, Y, Tashiro, S
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