XPO1 (CRM1) binds to BACH1:Hemes

Stable Identifier
R-HSA-9708430
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A small but significant fraction of XPO1 (CRM1) binds to BACH1. Several cysteine–proline (CP) dipeptide sequence in BACH1 are involved in heme binding, they also contain a nuclear export signal. The simplest model is that this region is involved in a heme-regulated interaction with XPO1 that mediates nuclear export. While XPO1 bound to BACH1 in GST pull-down assays, the nature of this interaction has yet to be extensively characterized (Suzuki et al, 2004).
Literature References
PubMed ID Title Journal Year
15175654 Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

Sun, J, Hira, S, Yamazaki, C, Yoshida, M, Igarashi, K, Ikeda-Saito, M, Suzuki, H, Zenke, Y, Tashiro, S

EMBO J 2004
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!