XPO1 (CRM1) binds to BACH1:Hemes

Stable Identifier
R-HSA-9708430
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A small but significant fraction of XPO1 (CRM1) binds to BACH1. Several cysteine–proline (CP) dipeptide sequence in BACH1 are involved in heme binding, they also contain a nuclear export signal. The simplest model is that this region is involved in a heme-regulated interaction with XPO1 that mediates nuclear export. While XPO1 bound to BACH1 in GST pull-down assays, the nature of this interaction has yet to be extensively characterized (Suzuki et al, 2004).

Literature References
PubMed ID Title Journal Year
15175654 Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

Suzuki, H, Tashiro, S, Hira, S, Sun, J, Yamazaki, C, Zenke, Y, Ikeda-Saito, M, Yoshida, M, Igarashi, K

EMBO J 2004
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