PGRMC2:Hemes dissociates

Stable Identifier
R-HSA-9707856
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Free heme behaves differently in the nucleus, in the absence of PGRMC2. This implies that heme may separate from the PGRMC2:heme complex. The exact conditions under which dissociation might occur are unknown (Galmozzi et al, 2019).

Literature References
PubMed ID Title Journal Year
31748741 PGRMC2 is an intracellular haem chaperone critical for adipocyte function

Galmozzi, A, Kok, BP, Kim, AS, Montenegro-Burke, JR, Lee, JY, Spreafico, R, Mosure, S, Albert, V, Cintron-Colon, R, Godio, C, Webb, WR, Conti, B, Solt, LA, Kojetin, D, Parker, CG, Peluso, JJ, Pru, JK, Siuzdak, G, Cravatt, BF, Saez, E

Nature 2019
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