FeHM oxidises LDL,HDL

Stable Identifier
R-HSA-9707586
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Heme binds and oxidizes lipoproteins
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Free heme initially binds to the lipoproteins LDL and HDL which are highly susceptible to oxidation by ferriheme (FeHM). The half-life of the heme:lipoprotein complex is longer than 20 sec. Heme is then transferred to the antioxidants albumin and hemopexin (Miller and Shaklai, 1999; Jeney et al, 2002)

Literature References
PubMed ID Title Journal Year
12130498 Pro-oxidant and cytotoxic effects of circulating heme

Jeney, V, Balla, J, Yachie, A, Varga, Z, Vercellotti, GM, Eaton, JW, Balla, G

Blood 2002
10381560 Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation

Miller, YI, Shaklai, N

Biochim Biophys Acta 1999
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