FeHM oxidises LDL,HDL

Stable Identifier
R-HSA-9707586
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Heme binds and oxidizes lipoproteins
ReviewStatus
5/5
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FeHM oxidises LDL,HDL
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Free heme initially binds to the lipoproteins LDL and HDL which are highly susceptible to oxidation by ferriheme (FeHM). The half-life of the heme:lipoprotein complex is longer than 20 sec. Heme is then transferred to the antioxidants albumin and hemopexin (Miller and Shaklai, 1999; Jeney et al, 2002)
Literature References
PubMed ID Title Journal Year
10381560 Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation

Miller, YI, Shaklai, N

Biochim Biophys Acta 1999
12130498 Pro-oxidant and cytotoxic effects of circulating heme

Jeney, V, Balla, J, Yachie, A, Varga, Z, Vercellotti, GM, Eaton, JW, Balla, G

Blood 2002
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Orthologous Events
FeHM oxidises LDL,HDL (Bos taurus)
FeHM oxidises LDL,HDL (Canis familiaris)
FeHM oxidises LDL,HDL (Gallus gallus)
FeHM oxidises LDL,HDL (Mus musculus)
FeHM oxidises LDL,HDL (Rattus norvegicus)
FeHM oxidises LDL,HDL (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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