FeHM oxidises LDL,HDL

Stable Identifier
R-HSA-9707586
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Heme binds and oxidizes lipoproteins
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Free heme initially binds to the lipoproteins LDL and HDL which are highly susceptible to oxidation by ferriheme (FeHM). The half-life of the heme:lipoprotein complex is longer than 20 sec. Heme is then transferred to the antioxidants albumin and hemopexin (Miller and Shaklai, 1999; Jeney et al, 2002)

Literature References
PubMed ID Title Journal Year
10381560 Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation

Shaklai, N, Miller, YI

Biochim Biophys Acta 1999
12130498 Pro-oxidant and cytotoxic effects of circulating heme

Eaton, JW, Jeney, V, Vercellotti, GM, Yachie, A, Balla, G, Varga, Z, Balla, J

Blood 2002
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
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