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oxidized LDL [extracellular region]
Stable Identifier
R-HSA-9707539
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
oxidized low-density lipoprotein complex
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
FeHM oxidises LDL,HDL (Homo sapiens)
oxidized LDL,HDL [extracellular region] (Homo sapiens)
oxidized LDL [extracellular region] (Homo sapiens)
General
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
Participants
components
APOB(28-4563) [extracellular region]
(Homo sapiens)
x 1500
CHEST [extracellular region]
x 670
CHOL [extracellular region]
oxidized phospholipids [extracellular region]
x 689
PL [extracellular region]
x 170
TAGs [extracellular region]
Participates
as a member of
oxidized LDL,HDL [extracellular region] (Homo sapiens)
Inferred To
oxidized LDL [extracellular region]
(Bos taurus)
oxidized LDL [extracellular region]
(Canis familiaris)
oxidized LDL [extracellular region]
(Gallus gallus)
oxidized LDL [extracellular region]
(Mus musculus)
oxidized LDL [extracellular region]
(Rattus norvegicus)
oxidized LDL [extracellular region]
(Sus scrofa)
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