Reactome | H2O2 oxidises ferrohemoglobin to MetHb

H2O2 oxidises ferrohemoglobin to MetHb

Stable Identifier

R-HSA-9707504

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Hemoglobin is oxidized by hydrogen peroxide

ReviewStatus

5/5

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Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily oxidized into methemoglobin (MetHb) in the presence of reactive oxygen species (ROS) like hydrogen peroxide (H2O2) (Gouveia et al, 2017; Sadrzadeh et al, 1984).

Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
6094553	Hemoglobin. A biologic fenton reagent Eaton, JW, Graf, E, Panter, SS, Hallaway, PE, Sadrzadeh, SM	J Biol Chem	1984
19968714	Biopreservation of red blood cells--the struggle with hemoglobin oxidation Acker, JP, Kanias, T	FEBS J	2010