Reactome | H2O2 oxidises ferrohemoglobin to MetHb

H2O2 oxidises ferrohemoglobin to MetHb

Stable Identifier

R-HSA-9707504

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Hemoglobin is oxidized by hydrogen peroxide

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily oxidized into methemoglobin (MetHb) in the presence of reactive oxygen species (ROS) like hydrogen peroxide (H2O2) (Gouveia et al, 2017; Sadrzadeh et al, 1984).

Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19968714	Biopreservation of red blood cells--the struggle with hemoglobin oxidation Kanias, T, Acker, JP	FEBS J	2010
6094553	Hemoglobin. A biologic fenton reagent Sadrzadeh, SM, Graf, E, Panter, SS, Hallaway, PE, Eaton, JW	J Biol Chem	1984