H2O2 oxidises ferrohemoglobin to MetHb

Stable Identifier
R-HSA-9707504
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Synonyms
Hemoglobin is oxidized by hydrogen peroxide
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Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily oxidized into methemoglobin (MetHb) in the presence of reactive oxygen species (ROS) like hydrogen peroxide (H2O2) (Gouveia et al, 2017; Sadrzadeh et al, 1984).

Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).

Literature References
PubMed ID Title Journal Year
19968714 Biopreservation of red blood cells--the struggle with hemoglobin oxidation

Kanias, T, Acker, JP

FEBS J 2010
6094553 Hemoglobin. A biologic fenton reagent

Sadrzadeh, SM, Graf, E, Panter, SS, Hallaway, PE, Eaton, JW

J Biol Chem 1984
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