Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily oxidized into methemoglobin (MetHb) in the presence of reactive oxygen species (ROS) like hydrogen peroxide (H2O2) (Gouveia et al, 2017; Sadrzadeh et al, 1984).Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).
Eaton, JW, Graf, E, Panter, SS, Hallaway, PE, Sadrzadeh, SM
Acker, JP, Kanias, T
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