RHOBTB GTPase Cycle

Stable Identifier
R-HSA-9706574
Type
Pathway
Species
Homo sapiens
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RHO BTB family belongs to atypical RHO GTPases, which are characterized by the absence of GTPase activity. RhoBTB family includes RHOBTB1, RHOBTB2, and the more divergent RHOBTB3. RHOBTB1 is a component of a signaling cascade that regulates vascular function and blood pressure (Ji and Rivero 2016). RHOBTB2 is involved in COP9 signalosome-regulated and CUL3-dependent protein ubiquitination (Berthold et al. 2008; Ji and Rivero 2016). RHOBTB3 participates in CUL3 dependent protein ubiquitination, vesicle transport, regulation of the cell cycle and modulating the adaptive response to hypoxia (Berthold et al. 2008; Ji and Rivero 2016).

Literature References
PubMed ID Title Journal Year
18298893 Rho GTPases of the RhoBTB subfamily and tumorigenesis

Berthold, J, Schenkova, K, Rivero, F

Acta Pharmacol. Sin. 2008
27314390 Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Ji, W, Rivero, F

Cells 2016
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