RHOBTB GTPase Cycle

Stable Identifier
R-HSA-9706574
DOI
10.3180/R-HSA-9706574.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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RHOBTB GTPase Cycle
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RHO BTB family belongs to atypical RHO GTPases, which are characterized by the absence of GTPase activity. RhoBTB family includes RHOBTB1 and RHOBTB2. RHOBTB3 is sometimes classified as the third RhoBTB family member, but it is divergent from the other two RHOBTBs and from Rho GTPases in general. RHOBTB1 is a component of a signaling cascade that regulates vascular function and blood pressure (Ji and Rivero 2016). RHOBTB2 is involved in COP9 signalosome-regulated and CUL3-dependent protein ubiquitination (Berthold et al. 2008; Ji and Rivero 2016).
Literature References
PubMed ID Title Journal Year
27314390 Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Ji, W, Rivero, F

Cells 2016
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Events
Participates
as an event of
Orthologous Events
RHOBTB GTPase Cycle (Bos taurus)
RHOBTB GTPase Cycle (Canis familiaris)
RHOBTB GTPase Cycle (Dictyostelium discoideum)
RHOBTB GTPase Cycle (Drosophila melanogaster)
RHOBTB GTPase Cycle (Gallus gallus)
RHOBTB GTPase Cycle (Mus musculus)
RHOBTB GTPase Cycle (Rattus norvegicus)
RHOBTB GTPase Cycle (Sus scrofa)
RHOBTB GTPase Cycle (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-03-06)
Reviewed
Fort, P  (2021-02-05)
Rivero Crespo, F  (2020-10-13)
Created
Orlic-Milacic, M  (2020-11-07)
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