RHOBTB GTPase Cycle

Stable Identifier
R-HSA-9706574
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

RHO BTB family belongs to atypical RHO GTPases, which are characterized by the absence of GTPase activity. RhoBTB family includes RHOBTB1 and RHOBTB2. RHOBTB3 is sometimes classified as the third RhoBTB family member, but it is divergent from the other two RHOBTBs and from Rho GTPases in general. RHOBTB1 is a component of a signaling cascade that regulates vascular function and blood pressure (Ji and Rivero 2016). RHOBTB2 is involved in COP9 signalosome-regulated and CUL3-dependent protein ubiquitination (Berthold et al. 2008; Ji and Rivero 2016).

Literature References
PubMed ID Title Journal Year
27314390 Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Ji, W, Rivero, F

Cells 2016
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!