RHOBTB3 binds interacting proteins at trans-Golgi network

Stable Identifier
Reaction [binding]
Homo sapiens
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RHOBTB3, like other RHOBTB family members, RHOBTB1 and RHOBTB2, binds CUL3 (cullin 3) a core component of BTB:CUL3:RBX1 E3 ubiquitin ligase complexes (Berthold et al. 2008). The following proteins are substrates of RHOBTB3-dependent ubiquitin ligase complexes:
RAB9A, RAB9B (Espinosa et al. 2009)
Cyclin E1 (Lu and Pfeffer 2013)
LRRC41 (MUF1) (Schenková et al. 2012).

The following proteins bind directly to RHOBTB3 but there is no evidence that they are substrates of RHOBTB3-dependent ubiquitin ligase complexes:
HGS (HRS) (Pridgeon et al. 2009)
PLIN3 (TIP47) (Espinosa et al. 2009)
5-HT7a serotonin receptor (Matthys et al. 2012)
VHL (Zhang et al. 2015).
Literature References
PubMed ID Title Journal Year
22709582 MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein

Schenkova, K, Lutz, J, Ramos, S, Kopp, M, Rivero, F

J Mol Biol 2012
22245496 RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation

Van Craenenbroeck, K, Lintermans, B, Vanhoenacker, P, Matthys, A, Haegeman, G

Cell Signal 2012
26215701 RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

Ma, T, Wu, D, Liu, Q, Li, M, Lin, SC, Jia, W, Wang, X, Guo, H, Cui, J, Peng, Y, Zhang, CS, Li, TY, Lin, SY, Ye, Z, Fu, Q, Zong, Y, Lian, G, Pu, C

Cell Res 2015
24145166 Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression

Pfeffer, SR, Lu, A

J Cell Biol 2013
19019082 Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes

Sha, D, Chin, LS, Pridgeon, JW, Webber, EA, Li, L

FEBS J 2009
19490898 RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport

Espinosa, EJ, Calero, M, Sridevi, K, Pfeffer, SR

Cell 2009
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