Reactome | RHOBTB3 binds interacting proteins at trans-Golgi network

RHOBTB3 binds interacting proteins at trans-Golgi network

Stable Identifier

R-HSA-9706390

Type

Reaction [binding]

Species

Homo sapiens

Compartment

trans-Golgi network membrane, cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

RHOBTB3 binds interacting proteins at trans-Golgi network

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RHOBTB3, like other RHOBTB family members, RHOBTB1 and RHOBTB2, binds CUL3 (cullin 3) a core component of BTB:CUL3:RBX1 E3 ubiquitin ligase complexes (Berthold et al. 2008). The following proteins are substrates of RHOBTB3-dependent ubiquitin ligase complexes:
RAB9A, RAB9B (Espinosa et al. 2009)
Cyclin E1 (Lu and Pfeffer 2013)
LRRC41 (MUF1) (Schenková et al. 2012).

The following proteins bind directly to RHOBTB3 but there is no evidence that they are substrates of RHOBTB3-dependent ubiquitin ligase complexes:
HGS (HRS) (Pridgeon et al. 2009)
PLIN3 (TIP47) (Espinosa et al. 2009)
5-HT7a serotonin receptor (Matthys et al. 2012)
VHL (Zhang et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
24145166	Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression Pfeffer, SR, Lu, A	J Cell Biol	2013
19019082	Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes Sha, D, Chin, LS, Pridgeon, JW, Webber, EA, Li, L	FEBS J	2009
22709582	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein Schenkova, K, Lutz, J, Ramos, S, Kopp, M, Rivero, F	J Mol Biol	2012
22245496	RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation Van Craenenbroeck, K, Lintermans, B, Vanhoenacker, P, Matthys, A, Haegeman, G	Cell Signal	2012
19490898	RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport Espinosa, EJ, Calero, M, Sridevi, K, Pfeffer, SR	Cell	2009
26215701	RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect Ma, T, Wu, D, Liu, Q, Li, M, Lin, SC, Jia, W, Wang, X, Guo, H, Cui, J, Peng, Y, Zhang, CS, Li, TY, Lin, SY, Ye, Z, Fu, Q, Zong, Y, Lian, G, Pu, C	Cell Res	2015