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PALB2 mutants (BRCA1 binding) [nucleoplasm]
Stable Identifier
R-HSA-9704332
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to PALB2 loss of function (Homo sapiens)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
PALB2 mutants (BRCA1 binding) [nucleoplasm] (Homo sapiens)
Participants
members
PALB2 L21A [nucleoplasm]
(Homo sapiens)
PALB2 L24S [nucleoplasm]
(Homo sapiens)
PALB2 Y28C [nucleoplasm]
(Homo sapiens)
PALB2 L35P [nucleoplasm]
(Homo sapiens)
PALB2 R37H [nucleoplasm]
(Homo sapiens)
candidates
PALB2 E12* [nucleoplasm]
(Homo sapiens)
PALB2 L21F [nucleoplasm]
(Homo sapiens)
PALB2 L35F [nucleoplasm]
(Homo sapiens)
PALB2 R37C [nucleoplasm]
(Homo sapiens)
Participates
as an input of
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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