BAP1 binds BRCA1:BARD1 heterodimer

Stable Identifier
R-HSA-9701003
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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BAP1 binds BRCA1:BARD1 heterodimer
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BAP1 binds to the BRCA1:BARD1 complex mainly through interaction with BARD1, although BRCA1 enhances the interaction. Amino acid residues 182-365 of BAP1 bind to the RING domain of BARD1, but outside of the BRCA1-binding site in the BARD1 RING domain (Nishikawa et al. 2009).

Literature References
PubMed ID Title Journal Year
19117993 BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity

Kojima, R, Fukuda, M, Koike, A, Nishikawa, H, Ohta, T, Wu, W, Gomi, H

Cancer Res. 2009
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Authored
Orlic-Milacic, M  (2020-09-30)
Reviewed
Baer, RJ  (2020-11-04)
Created
Orlic-Milacic, M  (2020-09-23)
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