Packaging of Viral Genome Into C Capsids

Stable Identifier
R-HSA-9698925
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
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The preformed procapsids are made in the nucleus proximal to DNA replication compartments. Encapsidation of unit-length viral DNA genomes depends on a terminase complex interacting with a specialized PORT penton. Terminase machinery recognizes free genomic ends and threads a single genome length of DNA through the PORT channel into each capsid. This process begins and ends at pac elements within terminal repeated a sequences, proceeding in a directional manner (S component first) on concatemeric DNA. A 129-bp region contains both cis-acting pac elements (pac1 and pac2) and is sufficient to direct cleavage and packaging leaving single-base 3 ́ extensions at both genomic ends.
Once the capsid has aquired the genome, it is designated a C capsid. Three capsid forms accumulate in the nucleus of herpesvirus-infected cells: A capsids that lack both scaffold and packaged viral DNA, B capsids that contain scaffold but lack viral DNA, and C capsids, contains viral DNA in place of scaffold and probably represents nucleocapsids in the process of maturation.

Literature References
PubMed ID Title Journal Year
9696791 Identification of persistent RNA-DNA hybrid structures within the origin of replication of human cytomegalovirus

Prichard, MN, Jairath, S, Penfold, ME, St Jeor, S, Bohlman, MC, Pari, GS

J. Virol. 1998
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
viral infectious disease 934 Viral disease, virus infection, virus infection
Authored
Reviewed
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