Reactome | RND1 binds effectors

RND1 binds effectors

Stable Identifier

R-HSA-9696271

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Active GTP-bound RND1 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2005)
GRB7 (Vayssiere et al. 2000)
PLEKHG5 (Goh and Manser 2010)
PLXNA1 (Zanata et al. 2002)
STIP1 (de Souza et al. 2014)
STMN2 (Li et al. 2009)
UBXN11 (Katoh et al. 2002)

The following candidate RND1 effectors were reported in the high throughput screen by Bagci et al. 2020 or have been reported as RND1 effectors in some but not all studies:
ALDH3A2 (Bagci et al. 2020)
ANKRD26 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003, Mori et al. 2009: binding to active RND1; Bagci et al. 2020: no binding to active RND1)
CAV1 (Bagci et al. 2020)
CCDC88A (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
RRAS2 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)

RND1 does not interact with the following putative effectors that bind to active RND2 and/or RND3:
CKAP4 (Bagci et al. 2020)
CKB (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
GOLGA3 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
PICALM (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
24690281	STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth Nakao, LS, Lopes, MH, Mercadante, AF, Püschel, AW, Martins, VR, Zanata, SM, de Souza, LE, Bilek, ES, Moura Costa, MD	Exp. Cell Res.	2014
15738000	Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells Harada, A, Katoh, H, Negishi, M	J. Biol. Chem.	2005
11784792	Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse Rohm, B, Hovatta, I, Zanata, SM, Püschel, AW	J Neurosci	2002
11940653	Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers Harada, A, Katoh, H, Mori, K, Negishi, M	Mol. Cell. Biol.	2002
20811643	The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain Goh, LL, Manser, E	PLoS ONE	2010
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020
10664463	Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family Mirey, G, Chardin, P, Camonis, J, Zalcman, G, Vayssière, B, Ligensa, T, Weidner, KM, Mahé, Y	FEBS Lett.	2000
18996843	Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10 Ghavampur, S, Li, YH, Grenningloh, G, Bondallaz, P, Püschel, AW, Will, L	J. Biol. Chem.	2009
12842009	Rnd proteins function as RhoA antagonists by activating p190 RhoGAP Burridge, K, Ellerbroek, SM, Forget, MA, Settleman, J, Arthur, WT, Wennerberg, K, Hansen, SH, Der, CJ	Curr. Biol.	2003
19103606	Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP Nishioka, T, Kaibuchi, K, Kato, K, Murohara, T, Morita, Y, Takefuji, M, Matsuura, Y, Mori, K, Amano, M	J. Biol. Chem.	2009