Expression of DMRT1 in testis differentiation

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R-HSA-9690877
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Reaction [uncertain]
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Homo sapiens
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In the gonadal ridge, the DMRT1 gene is transcribed to yield mRNA and the mRNA is translated to yield DMRT1 protein (Jørgensen et al. 2012, Rahmoun et al. 2017 and inferred from mouse homologs). SOX9 and GATA4 bind the promoter of the DMRT1 gene and activate transcription of DMRT1 (Rahmoun et al. 2017 and inferred from mouse homologs). DMRT1 is initially expressed in Sertoli cells at 8-20 weeks of gestation (Jørgensen et al. 2012). Expression then shifts to spermatogonial cells.

Literature References
PubMed ID Title Journal Year
22899867 Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry

Jørgensen, A, Nielsen, JE, Blomberg Jensen, M, Græm, N, Rajpert-De Meyts, E

Mol. Hum. Reprod. 2012
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Rahmoun, M, Lavery, R, Laurent-Chaballier, S, Bellora, N, Philip, GK, Rossitto, M, Symon, A, Pailhoux, E, Cammas, F, Chung, J, Bagheri-Fam, S, Murphy, M, Bardwell, V, Zarkower, D, Boizet-Bonhoure, B, Clair, P, Harley, VR, Poulat, F

Nucleic Acids Res. 2017
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