Expression of DMRT1 in testis differentiation

Stable Identifier
R-HSA-9690877
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of DMRT1 in testis differentiation
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the gonadal ridge, the DMRT1 gene is transcribed to yield mRNA and the mRNA is translated to yield DMRT1 protein (Jørgensen et al. 2012, Rahmoun et al. 2017 and inferred from mouse homologs). SOX9 and GATA4 bind the promoter of the DMRT1 gene and activate transcription of DMRT1 (Rahmoun et al. 2017 and inferred from mouse homologs). DMRT1 is initially expressed in Sertoli cells at 8-20 weeks of gestation (Jørgensen et al. 2012). Expression then shifts to spermatogonial cells.

Literature References
PubMed ID Title Journal Year
22899867 Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry

Græm, N, Jørgensen, A, Nielsen, JE, Rajpert-De Meyts, E, Blomberg Jensen, M

Mol. Hum. Reprod. 2012
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Symon, A, Philip, GK, Chung, J, Clair, P, Boizet-Bonhoure, B, Bardwell, V, Rahmoun, M, Poulat, F, Murphy, M, Bagheri-Fam, S, Lavery, R, Rossitto, M, Laurent-Chaballier, S, Zarkower, D, Pailhoux, E, Bellora, N, Harley, VR, Cammas, F

Nucleic Acids Res. 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Dmrt1 in testis differentiation (Mus musculus)
Authored
May, B  (2020-05-31)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-06)
Cite Us!