Reactome | Formation of the GCN5-ATAC complex

Formation of the GCN5-ATAC complex

Stable Identifier

R-HSA-9677050

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KAT2A (also known as GCN5) histone acetyltransferase forms an evolutionarily conserved ATAC complex with the following proteins: DR1, KAT14 (also known as ATAC2 or CSRP2BP), MBIP, SGF29 (also known as STAF36 or CCDC101), TADA2A (also known as ADA2-A), TADA3 (also known as ADA3), WDR5, YEATS2 and ZZZ3 (also known as ATAC1) (Suganuma et al. 2008; Wang et al. 2008, Guelman et al. 2009). ATAC complex is involved in transcriptional regulation (Wang et al. 2008) and is essential for mammalian development (Guelman et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19103755	The double-histone-acetyltransferase complex ATAC is essential for mammalian development Zha, J, Lill, JR, Mao, Y, Wu, J, Wang, J, Guelman, S, Solloway, MJ, Pham, V, Kozuka, K	Mol. Cell. Biol.	2009
18838386	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein Xu, M, Martinez, E, Pan, S, Faiola, F, Wang, YL	J. Biol. Chem.	2008