p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm

Stable Identifier
R-HSA-9673322
Type
Reaction [transition]
Species
Homo sapiens
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NRAGE, NRIF, NADE, TRAF6 mediate, through unclear mechanisms, MAPK8 (aka JNK) activation by threonine and tyrosine phosphorylation. While active (phosphorylated) MAPK8 moves to the nucleus and phosphorylates transcription factors such as c-JUN and ATF2, these have not been implicated in p75-mediated cell death. p75 activates the intrinsic caspase pathway (involving mitochondrial release of cytochrome c, Apaf-1, and caspases-9) rather than the extrinsic (caspase-8) pathway activated by most other death receptors (Troy et al. 2002).

Literature References
PubMed ID Title Journal Year
12097334 Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases

Troy, CM, Friedman, JE, Friedman, WJ

J Biol Chem 2002
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