Reactome | Factor IXa binds protein S

Factor IXa binds protein S

Stable Identifier

R-HSA-9669959

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

FIX binds PROS1

ReviewStatus

3/5

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Protein S (PS or PROS1), a vitamin K dependent anticoagulation factor, binds to and inactivates coagulation factor IXa (FIXa) in vitro and in vivo (Chattopadhyay R et al. 2012; Plautz WE et al. 2018). Disruption of the interaction between PROS1 and FIXa has been shown to increase the rate of thrombus formation in mice (Plautz WE et al., 2018). PROS1 inhibits both free FIXa and FVIIIa-bound FIXa in the tenase complex, thereby directly suppressing FX activation (Chattopadhyay R et al. 2012). The FIXa heparin-binding exosite (HBE) is critical for PROS1 binding and inhibition of FIXa in physiological environments, including the activated platelet surface, in human plasma and in murine thrombosis models (Plautz WE et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
29419409	Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis Plautz, WE, Sekhar Pilli, VS, Cooley, BC, Chattopadhyay, R, Westmark, PR, Getz, T, Paul, D, Bergmeier, W, Sheehan, JP, Majumder, R	Arterioscler. Thromb. Vasc. Biol.	2018