Killing mechanisms

Stable Identifier
R-HSA-9664420
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Killing mechanisms
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The long-lasting Leishmania infection is established within macrophages in which the most effective killing response is the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). (Rossi and Fasel 2018). Additionally, autophagy has been described as an innate immune mechanism for eliminating intracellular pathogens, although its role in restricting Leishmania replication is unclear (Veras et al. 2019)

Literature References
PubMed ID Title Journal Year
29294040 How to master the host immune system? Leishmania parasites have the solutions!

Rossi, M, Fasel, N

Int. Immunol. 2018
26226952 Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210

Frank, B, de Oliveira Almeida Petersen, AL, Weber, H, Scholz, CJ, Stigloher, C, Mottram, JC, Schurigt, U, Marcu, A

Parasit Vectors 2015
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Events
Participates
as an event of
Event Information
Go Biological Process
positive regulation of cell killing (0031343)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI  (2020-01-29)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
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