Reactome | SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier

R-HSA-9661723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

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Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The solute carrier organic anion transporter family member 2B1 (SLCO2B1, aka OATPRP2, OATPB, SLC21A9), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (Kullak-Ublick et al. 2001). The predominant isoform in the liver is SLCO2B1 isoform 3 (Knauer et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
11159893	Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B	Gastroenterology	2001
23531488	Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant Knauer, MJ, Girdwood, AJ, Kim, RB, Tirona, RG	Mol. Pharmacol.	2013