Reactome | ANO1 transports cytosolic Cl- to extracellular region

ANO1 transports cytosolic Cl- to extracellular region

Stable Identifier

R-HSA-9659568

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

Cytosolic Cl- is transported to extracellular region by ANO1

ReviewStatus

5/5

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ANO1 transports cytosolic Cl- to extracellular region

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Calcium-activated chloride channels (CaCCs) are ubiquitously expressed and implicated in physiological processes such as sensory transduction, fertilization, epithelial secretion, and smooth muscle contraction. The anoctamin family of transmembrane proteins (ANO, TMEM16) belong to CaCCs and have been shown to transport Cl- ions when activated by intracellular Ca2+ (Galietta 2009, Huang et al. 2012). ANO1 and 2 possess Ca2+ activated Cl- transport activity (Yang et al. 2008, Scudieri et al. 2012) while the remaining members also show some demonstrable activity (Tian et al. 2012). All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22946059	Anoctamins are a family of Ca2+ activated Cl- channels Tian, Y, Schreiber, R, Kunzelmann, K	J. Cell. Sci.	2012
18724360	TMEM16A confers receptor-activated calcium-dependent chloride conductance Yang, YD, Cho, H, Koo, JY, Tak, MH, Cho, Y, Shim, WS, Park, SP, Lee, J, Lee, B, Kim, BM, Raouf, R, Shin, YK, Oh, U	Nature	2008
21984732	The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels Scudieri, P, Sondo, E, Ferrera, L, Galietta, LJ	Exp. Physiol.	2012