KCNQ4 transports K+ from the cytosol to the extracellular region

Stable Identifier
R-HSA-9659554
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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KCNQ4 located on the basal membrane of outer hair cells (OHCs) and the basolateral membrane of inner hair cells (inferred from the mouse homolog) transports potassium ions along the concentration gradient from the cytosol to the extracellular region (Kubisch et al. 1999 and inferred from the mouse homolog). The resulting efflux of potassium is believed to be responsible for the I(K,n) current that plays a role in setting the resting potential of the cell and in repolarization of the cell. Absence of KCNQ4 causes increased depolarization and degeneration of OHCs (inferred from the mouse homolog).

Literature References
PubMed ID Title Journal Year
10025409 KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

Kubisch, C, Schroeder, BC, Friedrich, T, L├╝tjohann, B, El-Amraoui, A, Marlin, S, Petit, C, Jentsch, TJ

Cell 1999
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Input
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Catalyst Activity

voltage-gated potassium channel activity of KCNQ4 tetramer [plasma membrane]

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