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NR1H2,3 binds the ANGPTL3 gene
Stable Identifier
R-HSA-9657836
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LXR binds the ANGPTL3 gene
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)
NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)
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Angiopoietin-Like 3 (ANGPTL3) is a direct target gene of the LXR:RXR heterodimer. Synthetic and endogenous oxysterol ligand administration to human HepG2 cells or mice results in increased mRNA and protein levels of ANGPTL3 (Kaplan R et al. 2003). An LXR response element (LXRE) was identified in the promoter of human ANGPTL3 which conferred ligand and receptor-specific regulation in luciferase cell reporter assays (Kaplan R et al. 2003). ANGPTL3 is a secreted protein that inhibits activity of lipoprotein lipase and endothelial lipase (Shimizugawa T et al. 2002), and the LXR-mediated upregulation of this gene likely contributes (along with hepatic lipogenesis) to the severe hypertriglyceridemia associated with use of LXR drugs (Inaba T et al. 2003)
Literature References
PubMed ID
Title
Journal
Year
12518032
Regulation of the angiopoietin-like protein 3 gene by LXR
Hernandez, M
,
Wright, SD
,
Waters, MG
,
Gan, FX
,
Kaplan, R
,
Zhang, T
,
Cai, TQ
J. Lipid Res.
2003
Participants
Input
ANGPTL3 gene [nucleoplasm]
(Homo sapiens)
NR1H2,3:RXR [nucleoplasm]
(Homo sapiens)
NR1H3, NR1H2 ligands [nucleoplasm]
Output
NR1H2,3:RXR:NR1H2,3 ligand:ANGPTL3 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)
Authored
Shamovsky, V (2019-02-20)
Reviewed
D'Eustachio, P (2018-12-29)
Repa, JJ (2019-08-09)
Cummins, CL (2019-08-09)
Created
Shamovsky, V (2019-08-09)
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