Expression of ANGPTL3 regulated by NR1H2 or NR1H3

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Reaction [uncertain]
Homo sapiens
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The angiopoietin-Like 3 (ANGPTL3) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. ANGPTL3 is a direct target gene of the LXR:RXR heterodimer. Synthetic and endogenous oxysterol ligand administration to human HepG2 cells or mice results in increased mRNA and protein levels of ANGPTL3 (Kaplan R et al. 2003). An LXR response element (LXRE) was identified in the promoter of human ANGPTL3 which conferred ligand and receptor-specific regulation in luciferase cell reporter assays (Kaplan R et al. 2003). ANGPTL3 is a secreted protein that inhibits activity of lipoprotein lipase and endothelial lipase (Shimizugawa T et al. 2002), and the LXR-mediated upregulation of this gene likely contributes (along with hepatic lipogenesis) to the severe hypertriglyceridemia associated with use of LXR drugs (Inaba T et al. 2003)

Literature References
PubMed ID Title Journal Year
12518032 Regulation of the angiopoietin-like protein 3 gene by LXR

Hernandez, M, Wright, SD, Waters, MG, Gan, FX, Kaplan, R, Zhang, T, Cai, TQ

J. Lipid Res. 2003
This event is regulated
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