CASTOR1 homodimer binds L-arginine and dissociates from GATOR2

Stable Identifier
R-HSA-9657619
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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The CASTOR1 homodimer interacts with the GATOR2 complex via the MIOS subunit of GATOR2 (Chantranupong et al. 2016, Gai et al. 2016). The ACT domains of CASTOR1 bind L-arginine (Chantranupong et al. 2016, Saxton et al. 2016, Xia et al. 2016, Gai et al. 2016) and CASTOR1:arginine dissociates from GATOR2, which then prevents GATOR1 from activating the GTPase of RRAGA,B (Chantranupong et al. 2016). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).

Literature References
PubMed ID Title Journal Year
28199306 KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Wolfson, RL, Chantranupong, L, Wyant, GA, Gu, X, Orozco, JM, Shen, K, Condon, KJ, Petri, S, Kedir, J, Scaria, SM, Abu-Remaileh, M, Frankel, WN, Sabatini, DM

Nature 2017
26972053 The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Chantranupong, L, Scaria, SM, Saxton, RA, Gygi, MP, Shen, K, Wyant, GA, Wang, T, Harper, JW, Gygi, SP, Sabatini, DM

Cell 2016
27648300 Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling

Xia, J, Wang, R, Zhang, T, Ding, J

Cell Discov 2016
28066558 Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway

Gai, Z, Wang, Q, Yang, C, Wang, L, Deng, W, Wu, G

Cell Discov 2016
27487210 Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Saxton, RA, Chantranupong, L, Knockenhauer, KE, Schwartz, TU, Sabatini, DM

Nature 2016
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