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NMS [extracellular region]
Stable Identifier
R-HSA-964796
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neuromedin-S, NMS_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
NMUR2 binds neuromedin-S (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
NMUR2:NMS [plasma membrane] (Homo sapiens)
NMS [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5H8A3 NMS
Gene Names
NMS
Chain
signal peptide:1-26, propeptide:27-69, propeptide:70-105, propeptide:106-108, peptide:109-141, propeptide:144-153
Reference Genes
BioGPS Gene:129521 NMS
COSMIC (genes):NMS NMS
CTD Gene:129521 NMS
dbSNP Gene:129521 NMS
ENSEMBL:ENSG00000204640 NMS
HGNC:32203 NMS
KEGG:hsa:129521 NMS
Monarch:129521 NMS
NCBI Gene:129521 NMS
OMIM:619337 NMS
UCSC:Q5H8A3 NMS
Reference Transcript
RefSeq:NM_001011717.1 NMS
Other Identifiers
11738954_at
129521
16883468
2496253
2496255
2496258
2496260
2496262
8043890
A_33_P3320832
GO:0001664
GO:0005576
GO:0007218
GO:0045475
HMNXSV003009035
ILMN_1679967
TC02000607.hg
Participates
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as an input of
NMUR2 binds neuromedin-S (Homo sapiens)
as a component of
NMUR2:NMS [plasma membrane] (Homo sapiens)
Inferred To
NMS [extracellular region]
(Bos taurus)
NMS [extracellular region]
(Canis familiaris)
NMS [extracellular region]
(Gallus gallus)
Nms [extracellular region]
(Mus musculus)
Nms [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001011717.1
ENSEMBL
ENST00000376865
,
ENSP00000366061
OpenTargets
ENSG00000204640
HPA
ENSG00000204640-NMS
PRO
Q5H8A3
Pharos - Targets
Q5H8A3
PDB
7W57
,
7W56
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