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EML4 trimerizes
Stable Identifier
R-HSA-9647746
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 trimerizes (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EML4, a microtubule binding protein involved in mitotic spindle formation, forms homotrimers. Trimerization involves the trimerization domain (TD) and the basic region of EML4 and is necessary for its association with the microtubules (Richards et al. 2015). Heterotrimerization of EML4 with other EML family members has not been examined.
Literature References
PubMed ID
Title
Journal
Year
25740311
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
O'Regan, L
,
Richards, MW
,
Bayliss, R
,
Fry, AM
,
Straube, A
,
Montgomery, JM
,
Roth, D
Biochem. J.
2015
Participants
Input
x 3
EML4 [cytosol]
(Homo sapiens)
Output
EML4 homotrimer [cytosol]
(Homo sapiens)
Participates
as an event of
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
Orthologous Events
EML4 trimerizes (Bos taurus)
EML4 trimerizes (Caenorhabditis elegans)
EML4 trimerizes (Canis familiaris)
EML4 trimerizes (Gallus gallus)
EML4 trimerizes (Mus musculus)
EML4 trimerizes (Rattus norvegicus)
EML4 trimerizes (Sus scrofa)
EML4 trimerizes (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2019-06-25)
Reviewed
Fry, AM (2019-09-30)
Bechstedt, S (2019-10-03)
Lucken, KJ (2019-09-30)
O'Regan, L (2019-09-30)
Created
Orlic-Milacic, M (2019-06-03)
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