Reactome | CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2

CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2

Stable Identifier

R-HSA-9640237

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2

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CASTOR1 in a heterodimer with CASTOR2 interacts with the GATOR2 complex via the MIOS subunit of GATOR2 (Chantranupong et al. 2016, Gai et al. 2016). The ACT domains of the CASTOR1 subunit bind L-arginine (Chantranupong et al. 2016, Saxton et al. 2016, Xia et al. 2016, Gai et al. 2016) and CASTOR1:arginine dissociates from GATOR2, which then prevents GATOR1 from activating the GTPase of RRAGA,B (Chantranupong et al. 2016). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
26972053	The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway Chantranupong, L, Scaria, SM, Saxton, RA, Gygi, MP, Shen, K, Wyant, GA, Wang, T, Harper, JW, Gygi, SP, Sabatini, DM	Cell	2016
28199306	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 Wolfson, RL, Chantranupong, L, Wyant, GA, Gu, X, Orozco, JM, Shen, K, Condon, KJ, Petri, S, Kedir, J, Scaria, SM, Abu-Remaileh, M, Frankel, WN, Sabatini, DM	Nature	2017
27648300	Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling Xia, J, Wang, R, Zhang, T, Ding, J	Cell Discov	2016
28066558	Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway Gai, Z, Wang, Q, Yang, C, Wang, L, Deng, W, Wu, G	Cell Discov	2016
27487210	Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 Saxton, RA, Chantranupong, L, Knockenhauer, KE, Schwartz, TU, Sabatini, DM	Nature	2016