Reactome | NPAS4 gene transcription is repressed by KCNIP3

NPAS4 gene transcription is repressed by KCNIP3

Stable Identifier

R-HSA-9639567

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - Regulation of NPAS4 gene expression (Homo sapiens)
        
        Regulation of NPAS4 gene transcription (Homo sapiens)
        
        NPAS4 gene transcription is repressed by KCNIP3 (Homo sapiens)

General

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NPAS4 gene transcription is repressed by KCNIP3

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Based on studies in mice, in the absence of neuronal activity-induced calcium influx, KCNIP3 (DREAM) is bound to the promoter of the NPAS4 gene and represses NPAS4 transcription (Mellström et al. 2014).

Participants

Input

NPAS4 gene [nucleoplasm] (Homo sapiens)

Output

NPAS4 mRNA [cytosol] (Homo sapiens)

Participates

as an event of

Regulation of NPAS4 gene transcription (Homo sapiens)

This event is regulated

Negatively by

Regulator

KCNIP3:Mg2+:NPAS4 gene [nucleoplasm] (Homo sapiens)

Active Unit

KCNIP3:Mg2+:NPAS4 gene [nucleoplasm]

Positively by

Regulator

Ca2+ [nucleoplasm]

Inferred From

Npas4 gene expression (Mus musculus)

Authored

Orlic-Milacic, M (2022-04-08)

Reviewed

Lin, Y (2022-07-29)

Created

Orlic-Milacic, M (2019-03-13)

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