NPAS4 binds ARNTL (BMAL1)

Stable Identifier
R-HSA-9634846
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 binds ARNTL (BMAL1)
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NPAS4 is a basic-helix-loop-helix (bHLH) transcription factor that needs to dimerize with another bHLH protein in order to be able to bind to target DNA. ARNTL (BMAL1) is a bHLH transcription factor that can form a transcriptionally active heterodimer with NPAS4 (Ooe et al. 2004). Based on co-immunoprecipitation of endogenous Npas4 and Arntl from mouse brain, Arntl may not be the preferred heterodimerization partner of Npas4, as Npas4 shows a higher affinity for Arnt and Arnt2 (Ooe et al. 2009).
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Orthologous Events
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NPAS4 binds ARNTL (BMAL1) (Drosophila melanogaster)
NPAS4 binds ARNTL (BMAL1) (Mus musculus)
NPAS4 binds ARNTL (BMAL1) (Rattus norvegicus)
NPAS4 binds ARNTL (BMAL1) (Sus scrofa)
NPAS4 binds ARNTL (BMAL1) (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-16)
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