Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p16INK4A LoF mutants (CDK4) [cytosol]
Stable Identifier
R-HSA-9630826
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of cellular response to stress (Homo sapiens)
Diseases of Cellular Senescence (Homo sapiens)
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects (Homo sapiens)
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 (Homo sapiens)
p16INK4A mutants do not bind CDK4 (Homo sapiens)
p16INK4A LoF mutants (CDK4) [cytosol] (Homo sapiens)
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects (Homo sapiens)
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 (Homo sapiens)
p16INK4A mutants do not bind CDK4 (Homo sapiens)
p16INK4A LoF mutants (CDK4) [cytosol] (Homo sapiens)
Participants
members
p16INK4A R24P [cytosol]
(Homo sapiens)
p16INK4A G23D [cytosol]
(Homo sapiens)
p16INK4A G35A [cytosol]
(Homo sapiens)
p16INK4A G35V [cytosol]
(Homo sapiens)
p16INK4A D74Y [cytosol]
(Homo sapiens)
p16INK4A T18_A19dup [cytosol]
(Homo sapiens)
p16INK4A A60V [cytosol]
(Homo sapiens)
p16INK4A A60R [cytosol]
(Homo sapiens)
p16INK4A G67_N71del [cytosol]
(Homo sapiens)
p16INK4A T77P [cytosol]
(Homo sapiens)
p16INK4A R80P [cytosol]
(Homo sapiens)
p16INK4A L97R [cytosol]
(Homo sapiens)
p16INK4A R99P [cytosol]
(Homo sapiens)
p16INK4A E88K [cytosol]
(Homo sapiens)
p16INK4A R112dup [cytosol]
(Homo sapiens)
candidates
p16INK4A G23S [cytosol]
(Homo sapiens)
p16INK4A G23V [cytosol]
(Homo sapiens)
p16INK4A G35E [cytosol]
(Homo sapiens)
p16INK4A G35R [cytosol]
(Homo sapiens)
p16INK4A G35W [cytosol]
(Homo sapiens)
p16INK4A A60S [cytosol]
(Homo sapiens)
p16INK4A A60E [cytosol]
(Homo sapiens)
p16INK4A T77S [cytosol]
(Homo sapiens)
p16INK4A L97P [cytosol]
(Homo sapiens)
Participates
as an input of
p16INK4A mutants do not bind CDK4 (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text