Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6

Stable Identifier
R-HSA-9630794
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
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Missense and nonsense mutations in the CDKN2A gene that result in amino acid substitutions in p16INK4A or p16INK4A truncations, impairing its ability to bind to CDK4 and CDK6, interfere with p16INK4A-mediated induction of cellular senescence in response to oncogenic signaling (Haferkamp et al. 2008).
Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).
Literature References
PubMed ID Title Journal Year
18843795 p16INK4a-induced senescence is disabled by melanoma-associated mutations

Becker, TM, Rizos, H, Haferkamp, S, Kefford, RF, Scurr, LL

Aging Cell 2008
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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BioModels Database
Authored
Orlic-Milacic, M  (2018-12-24)
Reviewed
Bennett, DC  (2019-04-23)
Hayward, NK  (2019-06-03)
Nathan, V  (2019-06-03)
Created
Orlic-Milacic, M  (2018-12-03)
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