KLF4 gene expression is stimulated by FOXO1,FOXO3

Stable Identifier
R-HSA-9625409
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KLF4 gene expression is stimulated by FOXO1,FOXO3
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Based on studies in mice, FOXO1 and possibly FOXO3 directly stimulate transcription of the KLF4 gene, encoding a transcription factor Krueppel-like factor 4. KLF4 inhibits proliferation of mouse B cells (Yusuf et al. 2008). KLF4 has been reported to transcriptionally repress FOXO1 gene (Tang et al. 2016). In hypothalamic orexigenic neurons, KLF4 positively regulates expression of AGRP (agouti-related protein), an established FOXO target (Imbernon et al. 2014).
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Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1,(FOXO3):KLF4 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1,(FOXO3) [nucleoplasm]
Inferred From
Klf4 gene expression is stimulated by FOXO1 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
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