SREBF1 gene expression is inhibited by FOXO1

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R-HSA-9625346
Type
Reaction [omitted]
Species
Homo sapiens
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FOXO1 directly represses transcription of the SREBF1 (SREBP1) gene, encoding Sterol regulatory element-binding protein 1, a transcriptional activator required for lipid homeostasis (Deng et al. 2012). FOXO1 binding interferes with recruitment of SREBF1 transcriptional activator NR1H3 (LXRA) to the SREBF1 promoter (Liu et al. 2010). CRY1, a transcriptional target of SREBF1, downregulates FOXO1 protein levels by promoting MDM2-mediated polyubiquitination and degradation of FOXO1 (Jang et al. 2016).

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