Transcription of the CAV1 gene, encoding caveolin-1, is directly stimulated by FOXO3. Caveolin-1 is the main constituent of plasma membrane caveolae, involved in negative regulation of growth factor receptor signaling, which may contribute to the establishment of a senescent or quiescent cell phenotype. CAV1 expression decreases in the S phase, but FOXO-mediated regulation of CAV1 expression is cell cycle independent (van den Heuvel et al. 2005, Nho et al. 2013, Sisci et al. 2013). Transcription of the CAV1 gene is also directly stimulated by FOXO1 (Roy et al. 2008).
Ferraro, A, Cesario, MG, Coroniti, R, Maris, P, Romeo, F, Sisci, D, Mauro, L, Trombino, GE, Morelli, C, Aquila, S, Andó, S, Maggiolini, M, Lanzino, M, Anselmo, W
Ignatenko, NA, Gerner, EW, Fultz, KE, Henkhaus, RS, Mora, J, Roy, UK
Peterson, M, Henke, CA, Nho, RS, Hergert, P
Burgering, BM, Schulze, A, van den Heuvel, AP
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