CAV1 gene expression is stimulated by FOXO1,FOXO3

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Reaction [omitted]
Homo sapiens
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Transcription of the CAV1 gene, encoding caveolin-1, is directly stimulated by FOXO3. Caveolin-1 is the main constituent of plasma membrane caveolae, involved in negative regulation of growth factor receptor signaling, which may contribute to the establishment of a senescent or quiescent cell phenotype. CAV1 expression decreases in the S phase, but FOXO-mediated regulation of CAV1 expression is cell cycle independent (van den Heuvel et al. 2005, Nho et al. 2013, Sisci et al. 2013). Transcription of the CAV1 gene is also directly stimulated by FOXO1 (Roy et al. 2008).

Literature References
PubMed ID Title Journal Year
24047697 The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness

Ferraro, A, Cesario, MG, Coroniti, R, Maris, P, Romeo, F, Sisci, D, Mauro, L, Trombino, GE, Morelli, C, Aquila, S, Andó, S, Maggiolini, M, Lanzino, M, Anselmo, W

Cell Cycle 2013
18444242 Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc

Ignatenko, NA, Gerner, EW, Fultz, KE, Henkhaus, RS, Mora, J, Roy, UK

Mol. Carcinog. 2008
23580232 FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas

Peterson, M, Henke, CA, Nho, RS, Hergert, P

PLoS ONE 2013
15458387 Direct control of caveolin-1 expression by FOXO transcription factors

Burgering, BM, Schulze, A, van den Heuvel, AP

Biochem. J. 2005
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