Initiation of HCMV DNA Replication

Stable Identifier
R-HSA-9624033
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
Locations in the PathwayBrowser
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DNA synthesis occurs in the nucleus and relies on a core set of virus-coded proteins composed of replication fork machinery that work together to promote replication initiation on the oriLyt region. DNA synthesis initiates in the vicinity of oriLyt as soon as essential virus encoded proteins appear, producing high molecular weight replication intermediates. Onset of viral DNA synthesis licenses transcription of a subset of the late class (L) of viral genes, many of which encode proteins that take part in virion assembly.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
disease by infectious agent 0050117 infectious disease
Authored
Reviewed
Created
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