BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1)

Stable Identifier
R-HSA-9622627
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1)
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Transcription of the BCL6 gene, encoding a pro-apoptotic transcriptional repressor, is directly stimulated by FOXO3 (Fernandez de Mattos et al. 2004) and FOXO4 (AFX) (Tang et al. 2002). FOXO1 stimulates BCL6 gene transcription (Shore et al. 2006), but direct binding of FOXO1 to the BCL6 gene promoter has not been demonstrated.
Literature References
PubMed ID Title Journal Year
15509806 FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism

Nelson, BH, Fernández de Mattos, S, Martino, A, Brosens, JJ, Birkenkamp, KU, Lam, EW, Soeiro, I, Pietersen, AM, Essafi, A, Edwards, CS, Coffer, PJ, Francis, JM, Jones, MC

Mol. Cell. Biol. 2004
11777915 The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor

Dowbenko, D, Lewin, DA, Dent, AL, Tang, TT, Lasky, LA, Toney, L, Jackson, A

J. Biol. Chem. 2002
16943287 Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A

White, PC, Lam, EW, Shore, AM, Brennan, P, Essafi, A, Hui, RC, Rowe, M

J. Virol. 2006
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
FOXO3,FOXO4,(FOXO1):BCL6 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3,FOXO4,(FOXO1) [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-01)
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