RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4

Stable Identifier
R-HSA-9620813
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4
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Transcription of the RBL2 gene is directly stimulated by FOXO family transcription factors FOXO1, FOXO3 and FOXO4 (Kops et al. 2002, Chen et al. 2006). Direct transcriptional stimulation by human FOXO4 was demonstrated for human RBL2 gene (Kops et al. 2002), and by human FOXO1 and FOXO3 for mouse Rbl2 gene (Chen et al. 2006). The retinoblastoma family member RBL2 is needed for the establishment and maintenance of quiescent, G0, state.
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Output
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as an event of
This event is regulated
Positively by
Regulator
FOXO1,FOXO3,FOXO4:RBL2 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1,FOXO3,FOXO4 [nucleoplasm]
Inferred From
Rbl2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-09-25)
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