FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4

Stable Identifier
R-HSA-9617996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4
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In response to TGF-beta signaling, forkhead box transcription factors FOXO1, FOXO3 and FOXO4 bind to phosphorylated SMAD2/3:SMAD4 trimers by direct interaction between FOXO proteins and SMAD3 or SMAD4. FOXO proteins do not interact with all splicing isoforms of SMAD2 (Seoane et al. 2004).

Literature References
PubMed ID Title Journal Year
15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Massague, J, Shen, L, Le, HV, Anderson, SA, Seoane, J

Cell 2004
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Orthologous Events
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Danio rerio)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-31)
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