FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4

Stable Identifier
R-HSA-9617996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In response to TGF-beta signaling, forkhead box transcription factors FOXO1, FOXO3 and FOXO4 bind to phosphorylated SMAD2/3:SMAD4 trimers by direct interaction between FOXO proteins and SMAD3 or SMAD4. FOXO proteins do not interact with all splicing isoforms of SMAD2 (Seoane et al. 2004).

Literature References
PubMed ID Title Journal Year
15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Seoane, J, Le, HV, Shen, L, Anderson, SA, Massague, J

Cell 2004
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Orthologous Events
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Created