CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4

Stable Identifier
R-HSA-9617848
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Promoter of the CDKN1B gene, encoding CDK inhibitor p27Kip1, contains forkhead box elements that are required for induction of CDKN1B gene transcription by FOXO transcription factors FOXO1, FOXO3 (Dijkers et al. 2000, Lees et al. 2008) and FOXO4 (Medema et al. 2000). Direct binding of FOXO transcription factors to the CDKN1B gene promoter has not been demonstrated. Acetylation of FOXO4 by EP300 (p300) or CREBBP (CBP) in response to oxidative stress interferes with FOXO4-mediated induction of CDKN1B gene transcription (Dansen et al. 2009).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1,FOXO3,FOXO4 [nucleoplasm] (Homo sapiens)
Inferred From
Cdkn1b gene expression is stimulated by FOXO1,FOXO3 (Rattus norvegicus)
Cdkn1b gene expression is stimulated by FOXO4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
Cite Us!