Reactome | SGTA binds mislocalized membrane protein

SGTA binds mislocalized membrane protein

Stable Identifier

R-HSA-9617595

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SGTA binds mislocalized membrane protein

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Membrane proteins are not delivered to membranes with complete efficiency and a portion can end up mislocalized to the cytosol. SGTA binds the hydrophobic regions of such mislocalized proteins that are exposed to the cytosol (Leznicki and High 2012, Xu et al. 2012, Wunderly et al. 2014, Shao et al. 2017). Client proteins of SGTA include both tail-anchored proteins destined for insertion into the endoplasmic reticulum membrane (Leznicki et al. 2013) and inappropriately localized proteins such as cytosolic PRNP (PrP) (Leznicki and High 2012), which is normally located in the plasma membrane. Mislocalized proteins bound by SGTA can be routed to the proteasome via ubiquitination by the BAG6 complex (BAG6:GET4:UBL4A) (Shao et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
23246001	SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation Xu, Y, Cai, M, Yang, Y, Huang, L, Ye, Y	Cell Rep	2012
23129660	SGTA antagonizes BAG6-mediated protein triage Leznicki, P, High, S	Proc. Natl. Acad. Sci. U.S.A.	2012
23533635	The association of BAG6 with SGTA and tail-anchored proteins Leznicki, P, Roebuck, QP, Wunderley, L, Clancy, A, Krysztofinska, EM, Isaacson, RL, Warwicker, J, Schwappach, B, High, S	PLoS ONE	2013
25179605	SGTA regulates the cytosolic quality control of hydrophobic substrates Wunderley, L, Leznicki, P, Payapilly, A, High, S	J. Cell. Sci.	2014
28104892	Mechanistic basis for a molecular triage reaction Shao, S, Rodrigo-Brenni, MC, Kivlen, MH, Hegde, RS	Science	2017