HCMV Final Envelopment

Stable Identifier
R-HSA-9610954
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
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As part of the HCMV Vesicle Formation Complex, Vps4 controls the release of ESCRT complexes from membranes. Upstream ESCRT complexes ESCRT-I and ESCRT-II are believed to work in parallel to recruit the cargo, whereas Vps4 and ESCRT-III work in series. Virus envelopment occurs by budding into endosomal vesicles, which fuse with the plasma membrane to release virions to the extracellular space. Accumulation of viral glycoproteins gM-gN and ESCRT proteins at the periphery of AC support this model of viral egress, where these proteins provide essential functions such as envelopment and endosomal budding before viral exit.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
19640981 Human cytomegalovirus exploits ESCRT machinery in the process of virion maturation

Tandon, R, AuCoin, DP, Mocarski, ES

J. Virol. 2009
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Event Information
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This event is regulated
Disease
Name Identifier Synonyms
viral infectious disease 934 arbovirus infectious disease, Viral disease, Viral infection NOS, Viral infection, unspecified (disorder), Viral infection NOS, Viral disease (disorder), Viral disease, Viral infection NOS (disorder), Viral Infection, virus infection, virus infection, Viral: [infection NOS] or [illness]
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