Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP

Stable Identifier
R-HSA-9610442
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A SGTA dimer bound to a tail-anchored (TA) protein binds the BAG6 complex (BAG6:GET4:UBL4A) via UBL4A (Winnefeld et al. 2006, Chartron et al. 2012, Xu et al. 2012, Leznicki et al. 2013, Darby et al. 2014, Kuwabara et al. 2015, Mock et al. 2015, Shao et al. 2017, also inferred from rabbit homologs in Mariappan et al. 2010). At some point, ASNA1 (TRC40) also binds the complex (Shao et al. 2017). SGTA interacts with the ubiquitin-like domain (UBL) of BAG6 and the UBL of UBL4A competes with BAG6 for binding to SGTA (Chartron et al. 2012, Xu et al. 2012, Leznicki et al. 2013, Darby et al. 2014, Shao et al. 2017).

Literature References
PubMed ID Title Journal Year
23246001 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation

Xu, Y, Cai, M, Yang, Y, Huang, L, Ye, Y

Cell Rep 2012
23142665 Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface

Chartron, JW, VanderVelde, DG, Clemons, WM

Cell Rep 2012
25713138 Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis

Kuwabara, N, Minami, R, Yokota, N, Matsumoto, H, Senda, T, Kawahara, H, Kato, R

J. Biol. Chem. 2015
23533635 The association of BAG6 with SGTA and tail-anchored proteins

Leznicki, P, Roebuck, QP, Wunderley, L, Clancy, A, Krysztofinska, EM, Isaacson, RL, Warwicker, J, Schwappach, B, High, S

PLoS ONE 2013
25535373 Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain

Mock, JY, Chartron, JW, Zaslaver, M, Xu, Y, Ye, Y, Clemons, WM

Proc. Natl. Acad. Sci. U.S.A. 2015
16777091 Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest

Winnefeld, M, Grewenig, A, Schnölzer, M, Spring, H, Knoch, TA, Gan, EC, Rommelaere, J, Cziepluch, C

Exp. Cell Res. 2006
28104892 Mechanistic basis for a molecular triage reaction

Shao, S, Rodrigo-Brenni, MC, Kivlen, MH, Hegde, RS

Science 2017
25415308 Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A

Darby, JF, Krysztofinska, EM, Simpson, PJ, Simon, AC, Leznicki, P, Sriskandarajah, N, Bishop, DS, Hale, LR, Alfano, C, Conte, MR, Martínez-Lumbreras, S, Thapaliya, A, High, S, Isaacson, RL

PLoS ONE 2014
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