Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D)

Stable Identifier
R-HSA-9609737
Type
Reaction [binding]
Species
Homo sapiens
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GluN1 (GRIN1) binds GluN2B (GRIN2B) and GluN2D (GRIN2D) to form a tri-heteromeric NMDA receptor (Dunah et al. 1998). The tetrameric structure of the GluN1:GluN2B:GluN2D (GRIN1:GRIN2B:GRIN2D) tri-heterotetramer, consisting of two molecules of GluN1 (GRIN1) and one molecule of each GluN2B (GRIN2B) and GluN2D (GRIN2D), is assumed to be similar to the cryo-EM structure of the Xenopus GluN1:GluN2A:GluN2B NMDA receptor (Lu et al. 2017).

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