ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG

Stable Identifier
R-HSA-9605600
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa & Paulson 1993, Okajima et al. 1999, Kitagawa & Paulson 1994) located on the Golgi membrane, mediate the transfer of sialic acid (Neu5Ac, N-acetylneuraminic acid) in an α2,3 linkage to the terminal galactose of Gal-beta-1,4-GlcNAc- sequences found on glycoproteins and glycolipids to form Type 2 monosialylgalactosylgloboside (Type 2 MSGG).

Increased sialylation has been associated with malignant transformation and metastasis. ST3GAL6 is highly expressed in patients with multiple myeloma (MM). Knockdown of ST3GAL6 has been shown to prolong survival in mice (Glavey et al. 2014).

Literature References
PubMed ID Title Journal Year
10206952 Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids

Okajima, T, Fukumoto, S, Miyazaki, H, Ishida, H, Kiso, M, Furukawa, K, Furukawa, K, Urano, T

J Biol Chem 1999
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
8288606 Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups

Kitagawa, H, Paulson, JC

J Biol Chem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL3,4,6 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created