Reactome | ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG

ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG

Stable Identifier

R-HSA-9605600

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG

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The alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa & Paulson 1993, Okajima et al. 1999, Kitagawa & Paulson 1994) located on the Golgi membrane, mediate the transfer of sialic acid (Neu5Ac, N-acetylneuraminic acid) in an α2,3 linkage to the terminal galactose of Gal-beta-1,4-GlcNAc- sequences found on glycoproteins and glycolipids to form Type 2 monosialylgalactosylgloboside (Type 2 MSGG).

Increased sialylation has been associated with malignant transformation and metastasis. ST3GAL6 is highly expressed in patients with multiple myeloma (MM). Knockdown of ST3GAL6 has been shown to prolong survival in mice (Glavey et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
8333853	Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase Kitagawa, H, Paulson, JC	Biochem Biophys Res Commun	1993
10206952	Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids Okajima, T, Fukumoto, S, Miyazaki, H, Ishida, H, Kiso, M, Furukawa, K, Furukawa, K, Urano, T	J Biol Chem	1999
8288606	Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups Kitagawa, H, Paulson, JC	J Biol Chem	1994