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RUNX1 binds NOTCH4 gene
Stable Identifier
R-HSA-9604703
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
RUNX1 binds NOTCH4 gene (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The transcription factor RUNX1 binds to runx response elements in intron 29 of the NOTCH4 gene (Li et al. 2018).
Literature References
PubMed ID
Title
Journal
Year
29101237
Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
Gao, Y
,
Chen, L
,
Li, Y
,
Liu, PP
,
Jin, C
,
Qin, L
,
Sun, S
,
Cheng, L
,
Bai, H
,
Wang, QF
Blood
2018
Participants
Input
NOTCH4 gene [nucleoplasm]
(Homo sapiens)
RUNX1 [nucleoplasm]
(Homo sapiens)
Output
RUNX1:NOTCH4 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Pre-NOTCH Transcription and Translation (Homo sapiens)
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
Authored
Orlic-Milacic, M (2018-04-05)
Reviewed
Haw, R (2018-05-01)
Created
Orlic-Milacic, M (2018-04-05)
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