AKT1 phosphorylates NOTCH4

Stable Identifier
R-HSA-9604328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 phosphorylates NOTCH4
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Recombinant human AKT1 phosphorylates recombinant human NICD4 on four AKT-target sites conserved in primates: S1495, S1847, S1865 and S1917 (Ramakrishnan et al. 2015).
Literature References
PubMed ID Title Journal Year
25740432 AKT and 14-3-3 regulate Notch4 nuclear localization

Ramakrishnan, G, Davaakhuu, G, Chung, WC, Zhu, H, Rana, A, Filipovic, A, Green, AR, Atfi, A, Pannuti, A, Miele, L, Tzivion, G

Sci Rep 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Physical Entity
p-T308,S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT1 phosphorylates NOTCH4 (Danio rerio)
AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)
AKT1 phosphorylates NOTCH4 (Mus musculus)
AKT1 phosphorylates NOTCH4 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-03)
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