AKT1 phosphorylates NOTCH4

Stable Identifier
R-HSA-9604328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Recombinant human AKT1 phosphorylates recombinant human NICD4 on four AKT-target sites conserved in primates: S1495, S1847, S1865 and S1917 (Ramakrishnan et al. 2015).

Literature References
PubMed ID Title Journal Year
25740432 AKT and 14-3-3 regulate Notch4 nuclear localization

Ramakrishnan, G, Davaakhuu, G, Chung, WC, Zhu, H, Rana, A, Filipovic, A, Green, AR, Atfi, A, Pannuti, A, Miele, L, Tzivion, G

Sci Rep 2015
Participants
Participates
Event Information
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Orthologous Events
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