Reactome | FUT3 transfers Fuc to Type 1 chains to form LeA

FUT3 transfers Fuc to Type 1 chains to form LeA

Stable Identifier

R-HSA-9603986

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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FUT3 transfers Fuc to Type 1 chains to form LeA

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The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 chains in an α1,4 linkage forms the Lewis A antigen (LeA). In Lewis negative (Le(a- b-)) individuals, FUT3 is inactivated by either of two mutations resulting in a single amino acid substitution in the catalytic region (Nishihara et al. 1993). LeA is found on red blood cells (~20%) and in saliva and other secretions (>90%) of Europeans. LeA is a water-soluble antigen and red blood cells acquire Lewis specificity by adsorbing it onto their surfaces from blood plasma.

Literature References

PubMed ID	Title	Journal	Year
1977660	A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase Kukowska-Latallo, JF, Larsen, RD, Nair, RP, Lowe, JB	Genes Dev.	1990
8240337	Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals Nishihara, S, Yazawa, S, Iwasaki, H, Nakazato, M, Kudo, T, Ando, T, Narimatsu, H	Biochem. Biophys. Res. Commun.	1993