Reactome | FUT2 transfers Fuc to LeA to form LeB

FUT2 transfers Fuc to LeA to form LeB

Stable Identifier

R-HSA-9603982

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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The FUT2 gene (originally named the Se gene) expresses galactoside 2-alpha-L-fucosyltransferase 2 present on the Golgi membrane. FUT2 catalyses the α1,2 addition of fucose (Fuc) to Type 1 and Type 2 oligosaccharide chains, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the terminal galactose (Gal) of the Lewis A antigen (LeA) in an α1,2 linkage forms the Lewis B antigen (LeB) (Kelly et al. 1995, Koda et al. 1997). LeB is found only in secretors in around 80% of Europeans. LeB is only formed when an individual inherits both FUT3 (Le) and FUT2 (Se) genes and around 80% of individuals inherit FUT2.

Literature References

PubMed ID	Title	Journal	Year
7876235	Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype Kelly, RJ, Lowe, JB, Lennon, GG, Giorgi, D, Rouquier, S	J. Biol. Chem.	1995
9219535	Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2) Wang, B, Soejima, M, Koda, Y, Kimura, H	Eur. J. Biochem.	1997