PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3

Stable Identifier
R-HSA-947514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In order to get a sulfur atom for subsequent sulfuration reactions, cysteine is first desulfurated by NFS1 which transfers it onto a cysteine of MOCS3, yielding a protein persulfide (Marelja et al, 2008).
Literature References
PubMed ID Title Journal Year
18650437 A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

Leimkühler, S, Nimtz, M, Stöcklein, W, Marelja, Z

J Biol Chem 2008
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Output
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as an event of
Catalyst Activity

cysteine desulfurase activity of PXLP-K198-NFS1-2 dimer [cytosol]

Physical Entity
PXLP-K198-NFS1-2 dimer [cytosol] (Homo sapiens)
Activity
cysteine desulfurase activity (GO:0031071)
Orthologous Events
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Gallus gallus)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)
Authored
Stephan, R  (2010-09-02)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-09-08)
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